Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment

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Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.

BACKGROUND Delayed hematopoietic recovery is a major drawback of umbilical cord blood (UCB) transplantation. Transplantation of ex vivo-expanded UCB shortens time to hematopoietic recovery, but long-term, robust engraftment by the expanded unit has yet to be demonstrated. We tested the hypothesis that a UCB-derived cell product consisting of stem cells expanded for 21 days in the presence of ni...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2014

ISSN: 0021-9738

DOI: 10.1172/jci74556